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By Hannah Messinger, Penn Medicine

The brain is one of the most complex systems in the body, controlling movement, memory, communication, emotion, thought, and more. Unfortunately, serious diseases and injuries such as stroke, dementia, and psychiatric disorders can impede and disable core functions in the brain. Now, thanks to recent advances in neuroscience, neuroengineering, and other converging fields, experts are exploring the use of neuromodulation—noninvasive brain stimulation—to restore these functions in the brain, and Penn Medicine has launched a new center to study this science.

The Penn Brain Science, Translation, Innovation, and Modulation (brainSTIM) Center brings together a team of leading neuroscientists, neurologists, psychiatrists, psychologists, and engineers at Penn using neuromodulation techniques to research, repair, and enhance human brain function—the first translational center of its kind in the region.

The brainSTIM Center is led by Roy Hamilton, MD, MS, a neurologist at the Penn Memory Center and an associate professor of Neurology and Physical Medicine and Rehabilitation at the Perelman School of Medicine in the University of Pennsylvania. The center will be a hub for developing new treatments that use neuromodulation—direct stimulation of the brain with electrical signals or magnets—to reorder, reorganize, and restore brain function in patients suffering from various types of neurologic disorders such as dementia and stroke and psychiatric disorders like anxiety.

Top row: Cara Kiernan Fallon, PhD, Karolina Lempert, PhD; Lasya Sreepada; MPH;
Bottom row: Emily Largent, PhD, JD, RN; Shana Stites, PsyD, MA, MS; and Dawn Mechanic-Hamilton, PhD, ABPP/CN

By Danny Yarnall

The Penn Memory Center Scholars Program — the cornerstone of PMC’s efforts to train the next generation of Alzheimer’s disease researchers — is now named after the man responsible for first launching the Center.  

The new title, The Christopher M. Clark Scholars Program at the Penn Memory Center (PMC), honors the late Dr. Clark, PMC founding director, for his contributions to Alzheimer’s research. This commitment also underscores the belief that perspectives from psychology and economics belong at the table just as much as neurology and geriatrics when it comes to our work. 

“Chris Clark was committed to a vision: excellence in Alzheimer’s disease diagnosis, care, and research required a diversity of disciplines and sciences working and learning together. The Christopher M. Clark Scholars Program was founded to fulfill that vision,” said PMC Co-Director Jason Karlawish, MD. “We seek to nurture and support the best minds and to instill in them the virtues Chris lived. He understood the value of listening, tolerance, and a consistent and unwavering commitment to professional ethics.”

Graphic visual representations of information and data from the Alzheimer’s Disease Facts and Figures report.

The number of persons living with dementia is expected to more than double by 2050, and more than half of primary care physicians feel the medical profession is unprepared to handle the increase in cases.

This and other challenges are detailed in the Alzheimer’s Association’s annual report Alzheimer’s Disease Facts and Figures. The report examines the state of Alzheimer’s Disease in America and includes a new special report, “On the Front Lines: Primary Care Physicians and Alzheimer’s Care in America,” that addresses the dearth in specialists, training, and confidence primary care physicians have in diagnosing and treating Alzheimer’s.

By Danny Yarnall

Pamela Bryan could tell her husband David was struggling. Social-distancing restrictions shrunk their world to their East Oak Lane home and David, who lives with Mild Cognitive Impairment, started faltering in his memory more than usual.

“I noticed a decline,” she said. “There were changes in his forgetfulness, like where he was, and I’d have to remind him that this was our house.”

Isolation has left many caregivers feeling overwhelmed by constant care and presence with their loved ones, with fewer options to find relief and time to themselves. Some people living with dementia are more vulnerable to confusion and decline as routines they grounded themselves in are disrupted. One pilot program from Penn Memory Center and Temple University is adapting to meet caregivers’ needs both now and in the future.

Once a resource for caregivers and their loved ones to receive in-home respite care and engagement, Time Out Respite Care is pivoting to an online pilot program called Time Out Weekly Smile.

By Danny Yarnall

In 2019, after a quarter-century of scholarship in theater arts, Anne Basting, PhD was a veteran in the theatre world and experienced on many stages, but none like the stage at Morgantown Care and Rehabilitation in Morgantown, Kentucky.

It was the opening for the first of three adaptations of Peter Pan, performed at 12 rural nursing homes scattered across the state. Their take on the classic children’s story was born out of hundreds of sessions facilitated by Dr. Basting and trained volunteers from her TimeSlips organization and performed by residents, volunteers, and staff.

“These residents, several of whom had not been out of their rooms for months, were about to welcome an audience to see them and their nursing home in a completely new light. They were inviting their audience to see beauty and meaning in a place where most people only see overwhelming loss,” Dr. Basting recalled in a virtual discussion with the Penn Memory Center on Wednesday, May 27.

By Danny Yarnall

The COVID-19 pandemic has left many healthcare providers scrambling for resources to treat cases over the last several months. And public health officials fear a resurgence in cases. Doctors and healthcare professionals may be forced into difficult decisions: whom do you save?

In a recent paper published in The BMJ, authors Andrew Peterson, PhD; Penn Memory Center Clark Scholar Emily Largent, JD, PhD, RN; and PMC Co-Director Jason Karlawish, MD, analyzed the ethics of allocating scarce medical resources in the COVID-19 pandemic while addressing potential harms to at-risk populations.

“The potential for [allocation decisions] to disproportionately affect vulnerable populations—including older adults, people from minority communities, or people with disabilities—is a particular concern,” the authors wrote.

We are a nation, a city, at a crossroads.

Driven by the unjust killings of George Floyd, Ahmaud Arbery, Breonna Taylor, and countless other Black individuals, Americans are confronting the painful truth that discrimination and systemic racism are present in our daily lives. Across the globe and within our own West Philadelphia neighborhoods, people are taking to the streets with a clear message: Black Lives Matter.

By Danny Yarnall

Emily Largent, PhD, JD, RN, was recently selected to be part of the Greenwall Foundation’s Faculty Scholars class of 2023.

“I’m thrilled to have the Greenwall Foundation’s support to work on my project, ‘Autonomy on the Precipice of Cognitive Decline,’ Dr. Largent said. “This project will examine—from ethical, legal, and social perspectives—how our evolving understanding of Alzheimer’s disease is redefining and reshaping the patient experience.”

By Danny Yarnall 

Three Penn Memory Center (PMC) research coordinators — Allie Weiss, Sidnei McCrea, and Olivia Sykes — are departing the center this summer as they prepare to begin their medical school careers.

Weiss joined PMC in 2017 and has been instrumental to the Phase III Biogen study as a research coordinator and conducting cognitive assessments for our Aging Brain Cohort (ABC) Study. She will attend Sidney Kimmel Medical College at Jefferson University.

“Her intelligence, dedication, and kindness were apparent in all the work she did during her time at the Penn Memory Center,” said PMC Co-Director David Wolk, MD. “Our staff, faculty, and patients will miss her, but we are very excited for the many contributions she will make as a physician.”