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At The Age of Aging, we often talk about the importance of physical activity and a healthy diet for brain longevity. However, one of the best things you can do to promote brain health as you age may also seem unlikely: hanging out with your friends.

In this episode, we explore the growing body of research linking social isolation and loneliness to cognitive decline and dementia risk. We’ll hear from older adults navigating loneliness, researchers studying its effects on the brain, and members of a unique housing community designed to help older adults stay connected.

Later, Terrence Casey, Jake Johnson, and Executive Producer Dr. Jason Karlawish reflect on what loneliness looks like in clinical practice, why social isolation can complicate dementia diagnosis and care, and what listeners can do to build stronger social connections throughout their lives.

At the Age of Aging, we often speak with researchers and clinicians who have devoted their careers to understanding dementia and caring for the people living with it. Less often, we hear what happens when dementia becomes personal for those same experts.

In this episode, neuropsychologist Dr. Emma Rhodes shares her experience caring for her father, Jack, following his diagnosis of dementia due to Alzheimer’s disease. In conversation with Penn Memory Center Director of Social Work Allison Lynn, Emma reflects on grief, stigma, caregiving, and the challenges of navigating life as both a dementia expert and a daughter. Then, Executive Producer Dr. Jason Karlawish and Editorial Director Terrence Casey unpack some of the interview’s most powerful moments, connecting Emma’s experience to broader lessons about caregiving and dementia care.

What makes a house a home? And what happens when that home no longer works for the person living in it? In this episode, we explore the emotional and practical challenges of downsizing and moving later in life — from letting go of decades of possessions to navigating dementia, family dynamics, and the fear of what comes next.

Welcome to our annual summer bonus episode of the Age of Aging, where our Penn Memory Center experts reflect on the latest research from the annual Alzheimer’s Association International Conference (AAIC). On today’s episode, Age of Aging Executive Producer and PMC Co-Director Dr. Jason Karlawish sat down with Co-Director Dr. David Wolk and Dr. Chris Brown to unpack their biggest takeaways from their time in London. They discuss everything from new blood-based biomarkers to the latest data on anti-amyloid and tau-targeting therapies as well as what the future of Alzheimer’s treatment may look like.

The Age of Aging will return for Season 6 in September, so please make sure you’re subscribed wherever you get your podcasts, and we’ll see you soon.

From time to time, the Penn Memory Center will share selected pieces from Making Sense of Alzheimer’s, a project that explores how people understand and live with Alzheimer’s disease. Through essays, stories, and reflections, this series brings forward voices from patients, caregivers, clinicians, researchers, artists, and writers.

Constance McBride took a long look around the assisted living facility, struck by the gender imbalance among her mother’s peers.

They were predominantly women — wives and mothers, shaped as children by the Great Depression, who had gone on to outlive their spouses. Many of these members of “The Lonely Girls” club were also plagued with memory loss.

Shortly after, the inspired McBride developed The Lonely Girls, a collection of seven sculptures depicting women suffering from Alzheimer’s disease. She is quick to point out that the sculptures are not meant to represent any specific woman, for the most part.

From time to time, the Penn Memory Center will share selected pieces from Making Sense of Alzheimer’s, a project that explores how people understand and live with Alzheimer’s disease. Through essays, stories, and reflections, this series brings forward voices from patients, caregivers, clinicians, researchers, artists, and writers.

Cognitive testing is an important part of aging and dementia research, but many people are unsure what the experience involves.

In this new video, Dawn Mechanic-Hamilton, PhD, director of cognitive fitness programs and neuropsychological services at the Penn Memory Center, explains why researchers use cognitive testing and what participants should expect during a visit.

At the Age of Aging, we are sometimes lucky enough to have too many great stories to fit into a single podcast episode. We ran into this fortunate circumstance last season with our episode, “Ambiguous Loss,” which shared the stories of two caregivers grappling with their loved one’s decline from dementia. On today’s mid-summer bonus episode, we share a third story we recorded that didn’t make the cut – not because it wasn’t good enough, but because it was too complete to be a piece of something else.

Margo Woodacre is an author, teacher, former state senator, and for eight years, the primary caregiver for her husband, Ernie, who was living with Alzheimer’s. In this standalone conversation, Woodacre reflects on caregiving, grief, identity, and the slow work of asking, “Who am I now?” that followed the loss of Ernie.

From time to time, the Penn Memory Center will share selected pieces from Making Sense of Alzheimer’s, a project that explores how people understand and live with Alzheimer’s disease. Through essays, stories, and reflections, this series brings forward voices from patients, caregivers, clinicians, researchers, artists, and writers.

On a rainy Tuesday, Carl Duzen pulls open the garage door to his Havertown home as his wife, Susan Jewett, watches from the dry kitchen.

He goes inside, dives into his toolbox — “he loves his tools,” Susan says — and finds a screwdriver. An old clunker of a television is positioned under the garage’s main light, and Carl starts unscrewing, pulling off the back and exposing the ‘tube.’

The TV, one of those old cathode ray tube sets, was long ago considered obsolete by a neighbor, but Carl sees something valuable, beautiful in the discarded piece of old technology.

A scientist by training, Carl has taken to alchemy in the last two years, turning what others call junk into works of art.

From time to time, the Penn Memory Center will share selected pieces from Making Sense of Alzheimer’s, a project that explores how people understand and live with Alzheimer’s disease. Through essays, stories, and reflections, this series brings forward voices from patients, caregivers, clinicians, researchers, artists, and writers.

Her car parked on the side of a steep Green Lane, Michele Davis looks out over her hometown.

Ahead, there’s the iconic Manayunk Bridge, the face of the neighborhood visible to passers-by on the Schuylkill Expressway. Below, there’s Main Street, where 20-somethings fill the streets on warm summer afternoons and the bars on cold winter nights.

Behind her is the Manayunk she knew as a child: the community center she sneaked into without a membership, the church she attended each weekend, the old neighbors’ homes which have since been sold to strangers.

She takes out the camera, frames the scene before her, presses the shutter, and…

*click*