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The Penn Memory Center and our partners are currently seeking the following people to join our multi-disciplinary team of health professionals:
Postdoctoral Fellow Irwin Lab
This is a position for a postdoctoral research fellow in the Irwin Lab (Penn Digital Neuropathology Lab) at the University of Pennsylvania to work on NIH-funded translational pathology-imaging projects in frontotemporal degeneration, Lewy body disorders, Alzheimer’s disease and related conditions including: 1) statistical modeling of disease progression using graph theoretical analyses of antemortem structural/functional imaging and digital measures of postmortem histopathology, 2) high resolution 7.0 T MRI ex vivo imaging-guided histopathological sampling and 3D reconstruction of cortical/subcortical structures and deep WM tracts.
In the Penn Digital Neuropathology Lab, we use a multidisciplinary approach merging techniques in “wet-lab” based histopathology of human brain tissue with “dry-lab” based image analysis and bioinformatics tools with the overarching goal of improving our understanding of brain-behavior relationships and the antemortem diagnosis of neurodegenerative disease.
Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to “work backwards” to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a tissue-guided biomarker discovery method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Interested candidates please send cover letter and CV to Dr. David Irwin (PI): dirwin@pennmedicine.upenn.edu